A 582941 HCl (848591-90-2(free base))
CAS No.
A 582941 HCl (848591-90-2(free base)) ( —— )
Catalog No. M22602 CAS No.
A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing propertiesA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 357 | In Stock |
|
10MG | 597 | In Stock |
|
25MG | 882 | In Stock |
|
50MG | 1350 | In Stock |
|
100MG | Get Quote | In Stock |
|
200MG | Get Quote | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameA 582941 HCl (848591-90-2(free base))
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NoteResearch use only, not for human use.
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Brief DescriptionA-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing propertiesA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).
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DescriptionA-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing propertiesA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAChR
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Recptorα7 nAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight316.83
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Molecular FormulaC17H21ClN4
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.CN1C[C@H]2CN(C[C@H]2C1)c3ccc(nn3)c4ccccc4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tietje K R , Anderson D J , Bitner R S , et al. Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties[J]. Cns Neuroence & Therapeutics, 2010, 14(1):65-82.
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