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A 582941 HCl (848591-90-2(free base))

CAS No.

A 582941 HCl (848591-90-2(free base)) ( —— )

Catalog No. M22602 CAS No.

A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing propertiesA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    A 582941 HCl (848591-90-2(free base))
  • Note
    Research use only, not for human use.
  • Brief Description
    A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing propertiesA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).
  • Description
    A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing propertiesA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS).In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit.A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    α7 nAChR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    --
  • Formula Weight
    316.83
  • Molecular Formula
    C17H21ClN4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.CN1C[C@H]2CN(C[C@H]2C1)c3ccc(nn3)c4ccccc4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tietje K R , Anderson D J , Bitner R S , et al. Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties[J]. Cns Neuroence & Therapeutics, 2010, 14(1):65-82.
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